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Recombinant Human RANTES (CCL5)

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产品名称: Recombinant Human RANTES (CCL5)
产品型号: Z100785
产品展商: ABM
产品文档: 无相关文档

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Recombinant Human RANTES (CCL5)


Recombinant Human RANTES (CCL5)  的详细介绍
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Alternative Names Regulation upon Activation Normal T cell Express Sequence, CCL5, SIS-delta, C-C motif chemokine 5, EoCP, Eosinophil chemotactic cytokine, Small-inducible cytokine A5, T cell-specific protein P228, TCP228, T-cell-specific protein RANTES, D17S136E, SCYA5
Description RANTES belongs to the family of chemotactic cytokines known as chemokines and is expressed by an early response gene. The synthesis of RANTES is induced by TNF-alpha and IL-1-alpha. RANTES is chemotactic for T cells, human eosinophils and basophils and plays an active role in recruiting leukocytes into inflammatory sites. RANTES also activates eosinophils to release eosinophilic cationic protein while being a potent activator of oxidative metabolism specific for eosinophils. RANTES increases the adherence of monocytes to endothelial cells and selectively supports the migration of monocytes and T lymphocytes expressing the cell surface markers CD4 and UCHL1.
Gene Symbol CCL5
Gene ID 6352
Accession No. P13501
Source E. coli
Appearance Lyophilized Powder
Molecular Weight 9.0 kDa
Endotoxin Level <1.0 EU/μg of recombinant protein as determined by the LAL method
Purity >95% as determined by SDS-PAGE
Gel Image Click To Enlarge
Bioactivity Determined by its ability to chemoattract human blood monocytes using a concentration range of 1-10 ng/mL.
Bioactivity Data Click To Enlarge
Formulation Lyophilized from a 0.2 μm filtered solution in PBS
Reconstitution A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Storage The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Usage For research use only. Not for diagnostic or therapeutic use.
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