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Recombinant Human IL6

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产品名称: Recombinant Human IL6
产品型号: Z101315
产品展商: ABM
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Recombinant Human IL6


Recombinant Human IL6  的详细介绍
Print Version
Alternative Names IL-6, IL-6/26 kDa protein, B cell stimulatory factor 2, BSF-2, B cell differentiation factor, BCDF, CTL differentiation factor, CDF, Hybridoma growth factor, Interferon beta-2, IFN-beta-2, IFNB2, HPGF, HSF, MGI-2
Recombinant Human Interleukin-6 (IL6)
Description IL-6 is a pleiotropic cytokine that participates in a wide variety of biological functions such as acute phase response, inflammation, hematopoiesis, bone metabolism and cancer. While produced mainly by stimulated monocytes, fibroblasts and endothelial cells, IL-6 is also known to be produced by macrophages, T cells, B lymphocytes, granulocytes, smooth muscle cells, eosinophils, chondrocytes, osteoblasts, mast cells, glial cells and keratinocytes, upon stimulation. Unlike murine IL-6 which is inactive on human cells, both human and murine IL-6 are equally active on murine cells. The IL-6 receptor is a strongly glycosylated protein of 80 kDa and a length of 449 amino acids (designated CD126). Recombinant human IL-6 is a 21 kDa, glycosylated protein that contains two disulfide bridges.
Gene Symbol IL6
Gene ID 3569
Accession No. P05231
Source CHO cells
Appearance Lyophilized Powder
Molecular Weight 21.0 kDa
Endotoxin Level <1.0 EU/μg of recombinant protein as determined by the LAL method.
Purity >95% as determined by SDS-PAGE
Bioactivity The ED(50) was determined by the dose-dependent stimulation of the proliferation of murine 7TD1 cells was found to be less than 0.1 ng/mL, corresponding to specific activity of 1.0 x 10^7 IU/mg.
Formulation Interleukin-6 was lyophilized from a 0.2 μm filtered PBS solution pH 7.0.
Reconstitution A quick spin of the vial followed by reconstitution in sterile PBS to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Storage The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Usage For research use only. Not for diagnostic or therapeutic use.
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