Anti-Epidermal Growth Factor Receptor (EGFR) Phospho-Tyr1197 Antibody

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产品名称: Anti-Epidermal Growth Factor Receptor (EGFR) Phospho-Tyr1197 Antibody

产品型号: Y052117

产品展商: ABM

产品文档: 无相关文档

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Anti-Epidermal Growth Factor Receptor (EGFR) Phospho-Tyr1197 Antibody

Anti-Epidermal Growth Factor Receptor (EGFR) Phospho-Tyr1197 Antibody 的详细介绍

Overview	Print Version
Product Name	Anti-Epidermal Growth Factor Receptor (EGFR) Phospho-Tyr1197 Antibody
Description	EGFR is a transmembrane glycoprotein that is a member of a family of protein tyrosine kinases crucial in maintaining a normal balance in cell growth and development. Growth factor receptors are involved not only in promoting the proliferation of normal cells but also in the aberrant growth of many types of human tumors. For example, the epidermal growth factor receptor (EGFR) is mutated and/or overexpressed in many common solid human squamous cell carcinomas including breast, brain, bladder, lung, gastric, head & neck, esophagus, cervix, vulva, ovary, and endometrium. Over-expression of the EGFR gene occurs in carcinomas with and without gene amplification. EGFR and erbB-2 are particularly important in breast cancer because increased production or activation has been associated with poor prognosis. EGFR belongs to a family of growth factor receptors, which also includes ErbB-2/HER-2, ErbB- 3/HER-3 and ErbB-4/HER-4. EGFR can heterodimerize with each of the members of this family.
Subtype	polyclonal
Application	WB, IHC, ELISA
Raised In	rabbit
Specificity	This affinity-purified antibody is directed against the phosphorylated form of human EGFR protein at the pY1197 residue. The product was affinity purified from monospecific antiserum by immunoaffinity purification. Antiserum was first purified against the phosphorylated form of the immunizing peptide. The resultant affinity purified antibody was then cross-adsorbed against the non-phosphorylated form of the immunizing peptide. Reactivity occurs against human EGFR pY1197 protein and the antibody is specific for the phosphorylated form of the protein. Reactivity with non-phosphorylated human EGFR is minimal by ELISA. A BLAST analysis was used to suggest cross reactivity with phosphorylated EGFR from human, mouse and rat sources. Reactivity of this antibody with EGFR from other species is unknown.
Immunogen	This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 1189-1199 of human EGFR protein.
Guarantee	abm guarantees that all our Anti-Epidermal Growth Factor Receptor (EGFR) Phospho-Tyr1197 Antibody will perform as described on this product webpage, if this is not the case we will provide you with a one-time replacement at no extra cost. Documentation and explanation of experiment conducted will be required when submitting a claim for replacement.
Properties
Formulation	Liquid
Quantity	100 μg
Clone	Polyclonal
Storage	This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Buffer	PBS, pH 7.4 with 0.05% sodium azide.
Concentration	1µg/ul
Purity	Affinity Purified
Isotype	IgG
Species Reactivity	human
Anti-Epidermal Growth Factor Receptor (EGFR) Phospho-Tyr1197 Antibody Images

Specific References
Y052117 has been referenced in 1 publication. Sartor, C.I. et al., (1997) The Role of EGF Receptor and STAT-3 Activation in Autonomous Proliferation of SUM-102PT Human Breast Cancer Cells. Cancer Research 57:978. Scambia G, et al., (1993) Expression of ras oncogene p21 protein in normal and neoplastic ovarian tissues: Correlation with histopathological features and receptors for estrogen, progesterone, and the epidermal growth factor. Am J Obstet gynecol 168:71-78. Henzen-Logmans, S.C., et al., (1993) Occurrence of epidermal growth factor receeptors in benign and malignant ovarian tumors and normal ovarian tissues: an immunohistochemical study. J Can Res Clin Oncol 188:303-307. Sibilia, M., A.B. et al., (2000). The EGF Receptor Provides an Essential Survival Signal for SOS-Dependent Skin Tumor Development. Cell 102, 211-220.

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