Anti-Nerve Growth Factor Receptor produced in mouse Antibody

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产品名称: Anti-Nerve Growth Factor Receptor produced in mouse Antibody

产品型号: Y062078

产品展商: ABM

产品文档: 无相关文档

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Anti-Nerve Growth Factor Receptor produced in mouse Antibody

Anti-Nerve Growth Factor Receptor produced in mouse Antibody 的详细介绍

Overview	Print Version
Product Name	Anti-Nerve Growth Factor Receptor produced in mouse Antibody
Description	Monoclonal Anti-Nerve Growth Factor Receptor antibody produced in mouse clone ME20.4, ascites fluid
Subtype	monoclonal
Application	WB,IHC,Flow Cyt
Raised In	mouse
Specificity	Recognizes the low affinity human NGFR p75 (also known as gp75^NGFR , p75^NGFR and p75^NTR).¹ The epitope recognized by the antibody exists within the third or fourth cysteine-rich repeats of the NGFR molecule. May be used in various immunoassays including inhibition of NGF binding to p75-NGFR and as a cholinergic immunotoxin.
Immunogen	human melanoma cell line WM245.
Guarantee	abm guarantees that all our Anti-Nerve Growth Factor Receptor produced in mouse Antibody will perform as described on this product webpage, if this is not the case we will provide you with a one-time replacement at no extra cost. Documentation and explanation of experiment conducted will be required when submitting a claim for replacement.
Properties
Formulation	Liquid
Quantity	100 μl
Clone	ME20.4
Storage	This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Buffer	PBS, pH 7.4 with 0.05% sodium azide.
Concentration	1µg/ul
Purity	ascites fluid
Isotype	IgG1
Species Reactivity	human,other
Specific References
Y062078 has been referenced in 1 publication. 1. Ross, A.H., et al., Characterization of nerve growth factor receptor in neural crest tumors using monoclonal antibodies. Proc. Natl. Acad. Sci. USA 81, 6681-6685, (1984)Yan, H., and Chao, M.V., Disruption of cysteine-rich repeats of the p75 nerve growth factor receptor leads to loss of ligand binding. J. Biol. Chem. 266, 12099, (1991)Dominici, C., et al., Immunohistochemical detection of p140trkA and p75LNGFR neurotrophin receptors in neuroblastoma. J. Neurooncol. 31, 57-64, (1997) Fine, A., et al., Learning impairments following injection of a selective cholinergic immunotoxin ME20.4 IgG-saporin into the basal nucleus of Meynert in monkeys. Neuroscience 81, 331, (1997) Vissavajjhala, P., Structural domains of the extracellular domain of human nerve growth factor receptor detected by partial proteolysis. Arch. Biochem. Biophys. 294, 244, (1992)

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