Anti-mouse Nerve Growth Factor Antibody

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产品名称: Anti-mouse Nerve Growth Factor Antibody

产品型号: Y051703

产品展商: ABM

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Anti-mouse Nerve Growth Factor Antibody

Anti-mouse Nerve Growth Factor Antibody 的详细介绍

Overview	Print Version
Product Name	Anti-mouse Nerve Growth Factor Antibody
Description	The neurotrophins ("neuro" means nerve and "trophe" means nutrient) are a family of soluble, basic growth factors which regulate neuronal development, maintenance, survival and death in the CNS and the PNS.1 NGF, the first member of the family to be discovered, was originally purified as a factor able to support survival of sympathetic and sensory spinal neurons in culture.2 It is synthesized and secreted by sympathetic and sensory target organs and provides trophic support to neurons as they reach their final target.3 Neurotrophin secretion also increases in the nervous system following injury. Schwann cells, fibroblasts, and activated mast cells normally synthesize NGF constitutively, however direct trauma and induced cytokines combine to increase neurotrophin production in these cells after injury.4 NGF is purified in three forms: the 7S, 2.5S and b. The 7S, 130 kDa, form occurs naturally in mouse submaxillary glands, and is a multimeric protein composed of two a, one b and two g subunits. The name is derived from its sedimentation co-efficient, 7S. The biologically active subunit is the b, which is a 26 kDa dimer composed of two identical 120 amino acid chains held together by hydrophobic interactions.5 The 2.5S form is 9 amino acids shorter than the b form, because of proteolysis that occurs during the purification process.6 The structural hallmark of all the neurotrophins is the characteristic arrangement of the disulfide bridges known as the cysteine knot, which has been found in other growth factors such as PDGF.7 There is a 95.8% homology between the rat and mouse forms, and a 85% homology between the human and mouse. NGF has been shown to regulate neuronal survival, development function and plasticity.8 Recently, involvement of NGF in processes not involving neuronal cells has been shown, such as asthma,9 psoriasis10 and wound healing.11 The biological effects of NGF are mediated by two receptors: TrkA, which is specific for NGF, and p75, which binds all the neurotrophins.12
Subtype	polyclonal
Application	WB, IHC
Raised In	Rabbit
Specificity	BDNF, NT-3, and NT-4/5: None.
Immunogen	Epitope: Highly purified 2.5 S mouse NGF (Accession P01139).
Guarantee	abm guarantees that all our Anti-mouse Nerve Growth Factor Antibody will perform as described on this product webpage, if this is not the case we will provide you with a one-time replacement at no extra cost. Documentation and explanation of experiment conducted will be required when submitting a claim for replacement.
Properties
Formulation	Liquid
Quantity	50μl
Clone	Polyclonal
Storage	This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Buffer	PBS, pH 7.4 with 0.05% sodium azide.
Concentration	1µg/ul
Purity	Affinity purified on immobilized antigen.
Isotype	IgG
Species Reactivity	human, mouse, rat
Anti-mouse Nerve Growth Factor Antibody Images


Specific References
Y051703 has been referenced in 1 publication. 1. Roux, P. et al. (2002) Prog. Neurobiol. 67, 203. 2. Levi-Montalcini, R. (1966) Harvey Lect. 60, 217. 3. Farinas, I. et al. (1998) Neuron 21, 325. 4. Levi-Montalcini, R.et al. (1996) Trends Neurosci. 19, 514. 5. Bradshaw, R.A. (1978) Ann. Rev. Biochem 47, 191. 6. Bocchini, V. and Angeletti, P.U. (1969) Proc. Natl. Acad. Sci. USA 64, 787. 7. McDonald, N.Q.et al. (1991) Nature 354, 411. 8. Huang, E.J. and Reichardt, L.F. (2001) Annu. Rev. Neurosci. 24, 677. 9. Freund V. and Frossard, N. (1994) Prog. Brain Res. 146, 335. 10. Raychaudhuri, S.P. and Raychaudhuri, S.K. (2004) Prog. Brain Res. 146, 433. 11. Kawamoto, K. and Matsuda, H. (2004) Prog. Brain. Res. 146, 369. 12. Teng, K.K. and Hempstead, B.L. (2004) Cell Mol. Life Sci. 61, 35.

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