Vincristine Sulfate | CAS 2068-78-2 | Blocks Mitotic Spindle

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产品名称: Vincristine Sulfate | CAS 2068-78-2 | Blocks Mitotic Spindle

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简单介绍

CAS:2068-78-2Formula:C46H56N4O10.H2SO4MW:923.1Appearance:WhitetoOffWhiteSolidPurity:98%

Vincristine Sulfate | CAS 2068-78-2 | Blocks Mitotic Spindle 的详细介绍

Vincristine.sulfate blocks mitotic spindle formation, which impedes the cell cycle in G2/M phase. Blocks binding of tubulin to microtubule proteins through. Also acts as inducer to apoptosis; initiates Raf-1 activation phosphorylation of Bcl-2 family proteins; and induction of p53 expression. Used as cancer chemotherapeutic agent. Plant alkaloid.

Additional Information

Synonyms	VCR sulfate, Leukocristine sulfate
Product #	V-1055
CAS #	2068-78-2
Chemical Name	22-OXOVINACLEUKOBLASTINE SULFATE
Formula	C₄₆H₅₆N₄O₁₀.H₂SO₄
MW	923.1
Appearance	White to Off White Solid
Purity	98%
Solubility	Coelenterazine and the derivatives can be reconstituted by dissolving in methanol or ethanol. Do not dissolve in dimethyl-sulfoxide (DMSO); extremely low solubility in water.
Melting Point	300 °C
Storage Temp	-20°C, St°Ck solutions 3 months at -20°C
Therapeutic Area	Oncological Disorders
Use	An apoptosis inducing anticancer agent

Additional Information

Merck Index	Merck Index: 13.10048.2001
MDL Number	MFCD08706469
ChemACX	X1008852-7
InChI	InChI=1S/C46H56N4O10.H2O4S/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6;1-5(2,3)4/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3;(H2,1,2,3,4)/t28-,37+,38-,39-,42+,43-,44-,45+,46+;/m1./s1
SMILES	CC[C@@]1(C[C@@H]2C[C@@](c3c(c4ccccc4[nH]3)CC[N@@](C2)C1)(c5cc6c(cc5OC)N([C@@H]7[C@]68CCN9[C@H]8[C@@](C=CC9)([C@H]([C@@]7(C(=O)OC)O)OC(=O)C)CC)C=O)C(=O)OC)O.OS(=O)(=O)O

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