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Tubacin
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产品名称:
Tubacin
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简单介绍
CAS:537049-40-4Formula:C41H43N3O7SMW:721.86Appearance:Off-WhiteSolidPurity:98%byHPLC
Tubacin
的详细介绍
Tubacin (Tubulin acetylation inducer) is a highly potent, selective, reversible, and cell-permeable inhibitor of histone deacetylase 6 (HDAC6, IC= 4 nM). Displays 1000-fold more selectivity for HDAC6 over other HDACs. It inhibits tubulin deacetylation in mammalian cells. Unlike trichostatin A (TSA), which is a broad spectrum HDAC inhibitor, tubacin is specific for the tubulin deacetylase activity of HDAC6. Tubacin causes increased acetylation of tubulin, accumulation of polyubiquitinated proteins, and apoptosis. It does not affect global histone deacetylation, gene-expression profiling, or cell cycle progression mediated tubulin deacetylation in mammalian cells.
Additional Information
Synonyms
N-[4-[(2R,4R,6S)-4-[[(4,5-Diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N'-hydroxyoctanediamide
Product #
T-2471
CAS #
537049-40-4
Chemical Name
N-[4-[(2R,4R,6S)-4-[[(4,5-Diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N'-hydroxyoctanediamide
Formula
C
41
H
43
N
3
O
7
S
MW
721.86
Appearance
Off-White Solid
Purity
98% by HPLC
Solubility
DMSO (~ 10 mg/ml)
Storage Temp
-20°C
Therapeutic Area
Oncological Disorders
Use
A selective inhibitor of HDAC6 induces DNA damage and sensitizes transformed cells to anticancer agents
Additional Information
MDL Number
MFCD18452824
ChemACX
X1851075-3
InChI
InChI=1S/C41H43N3O7S/c45-26-28-17-19-29(20-18-28)35-25-34(27-52-41-43-38(30-11-5-3-6-12-30)39(51-41)31-13-7-4-8-14-31)49-40(50-35)32-21-23-33(24-22-32)42-36(46)15-9-1-2-10-16-37(47)44-48/h3-8,11-14,17-24,34-35,40,45,48H,1-2,9-10,15-16,25-27H2,(H,42,46)(H,44,47)/t34-,35+,40+/m1/s1
SMILES
c1ccc(cc1)c2c(oc(n2)SC[C@H]3C[C@H](O[C@H](O3)c4ccc(cc4)NC(=O)CCCCCCC(=O)NO)c5ccc(cc5)CO)c6ccccc6
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