Biological Activity:
WAY-316606 is a novel potent and selective inhibitor of secreted frizzled-related protein-1 (sFRP-1) with an IC50 ~ 0.65 μM. It prevents sFRP-1 from interacting with Wnt and thus increases Wnt signaling. WAY-316606 can increase total bone area in a murine calvarial organ culture assay.
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Reference:
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