Biological Activity:SGC707 is a potent, selective and cell permeable allosteric protein arginine methyltransferase 3 (PRMT3) inhibitor with IC50 ~ 31 nM. It has >100-fold selectivity against 31 other methyltransferases and 250 other non-epigenetic targets. SGC707 engages PRMT3 and potently inhibits its methyltransferase activity in cells. It is also bioavailable and suitable for animal studies. This well-characterized chemical probe is an excellent tool to further study the role of PRMT3 in health and disease.How to Use:In vitro: SGC707 was used at 5-10 µM final concentration in various in vitro assays.In vivo: n/a Reference:
本公司网站所展示销售的产品仅供科研!
沪公网安备 31011202007337号